An 81% sensitivity for detection of an ectopic parathyroid adenoma using dualphase 99m tcsestamibi is comparable to the 82% sensitivity for detection of all parathyroid adenomas ectopic and normal locations reported in a recent metaanalysis of 1297 patients with primary hyperparathyroidism reported by castellani et al. The tumor was located in the superior mediastinum and was resected. To describe localization studies in nine patients with ectopic parathyroid adenomas in the aortopulmonary window. Percutaneous transsternal cryoablation of ectopic parathyroid. After performing spect, the mass was observed as upper mediastinal mass. Excision of an elusive tiny ectopic parathyroid adenoma. Surgery is the mainstay of treatment to remove the offending parathyroid adenoma. Ectopic locations of parathyroid adenomas can cause difficulty in their diagnosis and surgical treatment. In our case, first mibi scintigraphy couldnt locate ectopic adenoma.
Gamma probeassisted excision of an ectopic parathyroid adenoma located within the thymus. The inferior parathyroid glands and thymus are both formed from the third. Management of ectopic parathyroid adenoma in pregnancy. Ectopic parathyroid glands arising due to abnormal embryological migration are found in % of the population and these combined together account for 2025% of the cases of parathyroid adenoma and clinically present as php. We document a rare case of ectopic parathyroid adenoma in the. The location of ectopic parathyroid adenomas can be predicted from the embryology of parathyroid gland development. Ectopic parathyroid adenoma initially suspected to be a. Clinical presentation patients present with primary hyperparathyroidism. Excision of an elusive tiny ectopic parathyroid adenoma fulltext.
A parathyroid adenoma present in an ectopic site, in the anterior mediastinum, is a rare cause of persistent hyperparathyroidism. The majority of parathyroid adenomas are juxtathyroid and located immediately posterior or inferior to the thyroid gland. The other was localized by a technetium 99m sestamibi single photon emission ct spect. Persistent hyperparathyroidism due to mediastinal parathyroid adenoma localized by preoperative single photon emission computed tomography and intraoperative gamma probe application mehmet uludag1. A 42yearold female diagnosed as having gh secreting pituitary adenoma presented with an ectopic mediastinal parathyroid adenoma located between left lt pulmonary artery and lt main bronchus. Difficult to see on routine sestamibi scan if you dont know all the tricks. These glands are formed with the thymus gland and thyroid gland and during our growth inside our mothers womb. Eightyfive percent of all primary hyperparathyroidism is caused by parathyroid adenomas, whereas parathyroid hyperplasia and parathyroid carcinoma account for 15% and less than 1%, respectively. The migration of the parathyroid glands down from the base of the brain into the neck doesnt occur correctly in about 5% of people. We report a patient who underwent an intraoperative radionuclideguided thoracoscopic resection of an occult mediastinal ectopic parathyroid adenoma. Inability to locate the adenoma in an ectopic parathyroid gland may further. Primary hyperparathyroidism phpt caused by ectopic parathyroid adenomas in the mediastinum is uncommon.
Thus, we reported an unusual clinical case, in which a patient was diagnosed with ectopic giant parathyroid adenoma in mediastinum and with hypercalcemia. Parathyroid adenomas are benign tumors of the parathyroid glands, and are the most common cause of primary hyperparathyroidism. Epa causing primary hyperparathyroidism php is well known. We present a case of an ectopic mediastinal parathyroid adenoma detected with 4dimensional computed tomography 4dct in a patient with persistent primary hyperparathyroidism and failed neck exploration. Intraneural parathyroid adenomas are rare, with only 9 cases of intravagal adenomas reported. She required aggressive intravenous hydration with the addition of furosemide to enhance calcium elimination.
All but one of the reported cases was found after multiple neck explorations. Grossly, the tumor was seen to be wellcircumscribed. Superior gland parathyroid adenomas may lie posteriorly in the tracheoesophageal groove, paraesophageal location, or even as inferior as the mediastinum 12. Ectopic parathyroid adenomas can occur in various anatomical locations that may be missed even with the use of the various imaging modalities. A case report of mediastinal ectopic parathyroid adenoma. Ectopic parathyroid adenomas epas are not very rare and distribute in many locations, among which the thymus is very common. With the help of gamma probe, a soft tissue mass 1 cm in size was excised from anterior mediastinum in mediastinoscopy. Ectopic parathyroid adenoma the hidden culprit j muthukrishnan, a verma, kd modi, k kumaresan, sangeeta jha abstract primary hyperparathyroidism is known to present with protean manifestations leading to misdiagnosis in the initial stages of the disease.
Sixteen percent of parathyroid adenomas can be situated in an ectopic location. Ectopic parathyroid adenoma in thymus medcrave online. Parathyroidectomy has a success rate of 95 % for cure of primary hyperparathyroidism. A challenging case of an ectopic parathyroid adenoma. Most parathyroid adenomas are sporadic but there are inherited causes, most commonly multiple endocrine neoplasia type 1 men1. Primary hyperparathyroidism through an ectopic parathyroid adenoma. A human being usually has four parathyroid glands located on the back surface of the thyroid in the neck.
Traditionally this involved a bilateral cervical exploration to. Ectopic location of the parathyroid glad occurs in 616%. Parathyroid adenoma, a benign tumor and eventually solitary in about 90% of cases, is a significant cause of primary hyperparathyroidism phpt. Ectopic parathyroid glands and their anatomical, clinical and. Ectopic parathyroid adenoma high in the neck undescended parathyroid adenoma parathyroid glands are formed at the base of the brain while we are only 2 months gestation 7 months before we are born. Mediastinal ectopic parathyroid adenomas mepas are a rare cause of primary hyperparathyroidism, constituting 1%2% of all parathyroid adenomas. Exceptional localisation of an ectopic parathyroid adenoma. Request pdf ectopic parathyroid glands and their anatomical, clinical. In other instances when a focal adenoma is suggested at the thyroid axis on the technetium tc 99m sestamibi scan and the ultrasound scan fails to confirm the.
Ectopic parathyroid adenoma in the pyriform sinus kim. Unfortunately, parathyroid disorders will only get worse if left untreated. Up to 5% of parathyroid adenomas can occur in ectopic locations. Parathyroid glands that dont migrate down and remain high in the neck are called undescended. After localization of an ectopic adenoma in the mediastinum using nuclear medicine scanning, she underwent a videoassisted thoracoscopic resection of the mediastinal parathyroid adenoma. A 67yearold chinese male presented as a parathyroid crisis due to an ectopic mediastinal parathyroid adenoma with his serum calcium and pth markedly increased in short time.
The results of radiographic and cytologic studies may lead to confusion of these neoplasms with lesions of thyroid origin. In a small number of cases, recurrent renal stone diseases nephrolithiasis is due to an underlying metabolic condition. Larian at 3104610300 to schedule a consultation today. Ectopic mediastinal parathyroid adenoma as a cause of primary hyperparathyroidism phpt can normally be resected from conventional collar incision. There are many diagnostic methods to trace the parathyroid adenoma. Imaging studies were complemented by 99m tcsestamibi scintigraphyspectct which suspected the presence of an ectopic parathyroid adenoma in the right middle mediastinum nearby residual thymic tissue. T1 an occult ectopic parathyroid adenoma in a pediatric patient. To the best of our knowledge, we report the first case of nonsupernumerary ectopic intravagal parathyroid identified at primary exploration. James meek,1 savannah fletcher,1 marcus kessler,2 aparna komarraju,1. Further investigation with fchpetct confirmed the presence of a 6 mm parathyroid adenoma. Parathyroid crisis due to ectopic parathyroid adenomas can pose diagnostic and management challenges, since it is quite rare in clinical practice. We present a patient with concurrent parathyroid adenoma and thymoma.
Identifying an ectopic parathyroid adenoma using 4dct in a. In case of suspicion of a parathyroid adenoma a ct of the neck should be thoroughly assessed by a dedicated multidisciplinary team, including the head and neck surgeon, as clinical data and radiological findings must be combined since ectopic parathyroid adenomas are a rare entity. In conclu sion, spect and intraoperative gamma probe application may help to detect the parathyroid adenomas, especially if they are small in size and buried in the adipose tissue. Videoassisted thoracoscopic resection of a mediastinal. Frequently, however, one of these imaging studies is negative and invasive imaging studies may be required to further confirm the localization of an ectopic parathyroid adenoma. This variability in the location of adenomas is a challenge to surgeons and a justification for using preoperative localization procedures. Radiologic and cytologic examinations may cause misinterpretation of such lesions as thyroid tumors. Parathyroid tumors are usually located in the neck region or in ectopic location rarely found in mediastinum. This has been ascribed to a close embryological relationship between the two. An occult ectopic parathyroid adenoma in a pediatric. Eightyfive percent of the cases of php are due to the adenoma. Ectopic parathyroid tissue faintly visible arrow using.
British nuclear medicine society clinical guideline for. Ectopic parathyroid adenomas epas pose unique challenges in the management of patients with primary hyperparathyroidism. While ectopic parathyroid adenomas can rarely occur in the pharyngeal region, this has not previously been described in the soft palate. The most effective image technique to determine the ectopic parathyroid adenoma is tc 99m mibi scintigraphy, even though us. Ectopic parathyroid adenoma presenting as a mediastinal mass. We discuss the utility of 4dct in the localization of these lesions and offer an algorithm that implements the use of 4dct early on when standard imaging techniques are nonlocalizing. In each case, office endoscopy confirmed the lesions. Ectopic parathyroid adenomas article pdf available in journal of the royal society of medicine 739. The occurrence of ectopic parathyroid adenomas is not uncommon 34% of all parathyroid adenomas. We present a case of an ectopic parathyroid adenoma which prompted cytologic misdiagnosis and intraoperative suspicion of thyroid carcinoma. Adult ectopic cervical thymic tissue in relation to a. Case of primary hyperparathyroidism due to ectopic. Intraoperative radioguided thoracoscopic removal of ectopic. Ebrahimi et al describe more than one ectopic tissue in the form of ectopic parathyroid tissue within ectopic thymic tissue.
Visualization of ectopic parathyroid adenomas nejm. Vitamin d deficiency vdd is usually seen in elderly patients with phpt. Ectopic parathyroid adenoma high in the neck undescended. Nine patients with ectopic parathyroid tissue eight adenomas, one hyperplastic gland in the aortopulmonary window were examined with ultrasound us, computed tomography ct, magnetic resonance mr imaging, and scintigraphy. Ectopic parathyroid adenomas can occur in numerous anatomic locations. Large parathyroid adenomas are exceptional, and masses. This case report of a woman with an ectopic parathyroid adenoma suggests that simultaneous positronemission tomography pet and mri might be superior to petct for lesion localization. Pdf incidence and localization of ectopic parathyroid adenomas. We report the first case of ectopic parathyroid adenoma within the soft palate.
Spect showed a parathyroid adenoma in the middle of the anterior mediastinum which was excised size 1x0. Reported incidence of ectopic parathyroid adenomas is 516% 4,5. Intraoperative radioguided thoracoscopic removal of. Three patients, 2 after prior unsuccessful parathyroid exploration, were found to have ectopic parathyroid adenomas in the pyriform sinus. Localisation of ectopic mediastinal parathyroid adenoma by. Mediastinal parathyroid adenoma singapore medical journal. A 59 year old woman presented with hyperparathyroidism. Exact localization of ectopic parathyroid adenoma could be performed by fused spectct images.
We present a case of an ectopic parathyroid adenoma for. The patient subsequently had an uneventful delivery at term. Histopathological examinations were consistent with parathyroid adenoma. Incidence and location of ectopic abnormal parathyroid glands. A positive parathyroid sestamibi scan and a positive 4d ct scan may be all that is necessary to localize a mediastinal ectopic parathyroid adenoma.
Pdf ectopic parathyroid adenoma alexandros sfakianakis. Contact the center for advanced parathyroid surgery today. Ect has been described in the vicinity of a parathyroid adenoma 9, 10. Parathyroid glands, usually four, are localized at the anterior cervical level, in several positions, on the posterior side of the thyroid gland. Ectopic parathyroid adenomas in the piriform sinus are rare with only a few previously documented cases. Adenoma of the parathyroid gland is a frequent cause of hyperparathyroidism. Detection of ectopic parathyroid adenoma by early tc99m. Ectopic intravagal parathyroid adenoma daruwalla 2015. Thymus gland and ectopic inferior parathyroid adenomas. This includes primary hyperparathyroidism due to a parathyroid adenoma rarely these occur in an ectopic location, typically the mediastinum, rather than in the neck. Histopathological examination confirmed parathyroid adenoma. A parathyroid adenoma is a benign tumor of the parathyroid gland. Primary hyperparathyroidism through an ectopic parathyroid.
46 177 1120 379 714 172 225 1450 92 1379 1264 842 1172 1474 1208 866 672 1481 596 1467 193 717 1147 644 1365 884 1332 609 707 1073 682 766 94 829